|Function||thiazole/oxazole-forming peptide maturase, SagD family component|
|Domain Trusted Cutoff||219.25|
|Domain Noise Cutoff||94.10|
|Entry Date||May 2 2008 3:04PM|
|Last Modified||Aug 14 2012 2:34PM|
|Comment||Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.|
RT YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations.
RA Dunbar KL, Melby JO, Mitchell DA
RL Nat Chem Biol. 2012 Apr 22;8(6):569-75.
RT Discovery of a widely distributed toxin biosynthetic gene cluster.
RA Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE
RL Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84.|
|Genome Property||GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)|
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