HMM Summary Page: TIGR03604

Functionthiazole/oxazole-forming peptide maturase, SagD family component
Trusted Cutoff219.25
Domain Trusted Cutoff219.25
Noise Cutoff94.10
Domain Noise Cutoff94.10
Isology Typesubfamily_domain
HMM Length377
AuthorHaft DH
Entry DateMay 2 2008 3:04PM
Last ModifiedAug 14 2012 2:34PM
CommentMembers of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.
ReferencesRN [1] RM PMID:22522320 RT YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations. RA Dunbar KL, Melby JO, Mitchell DA RL Nat Chem Biol. 2012 Apr 22;8(6):569-75. RN [2] RM PMID:18375757 RT Discovery of a widely distributed toxin biosynthetic gene cluster. RA Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE RL Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84.
Genome PropertyGenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)