| Accession | TIGR03605 |
| Name | antibiot_sagB |
| Function | SagB-type dehydrogenase domain |
| Trusted Cutoff | 78.40 |
| Domain Trusted Cutoff | 78.40 |
| Noise Cutoff | 47.35 |
| Domain Noise Cutoff | 47.35 |
| Isology Type | domain |
| HMM Length | 173 |
| Author | Haft DH |
| Entry Date | May 5 2008 9:25AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | SagB of Sterptococcus pyogenes participates in the maturation of streptolysin S from a ribosomally produced precursor polypeptide. Chemically similar systems operate on highly diverse sets of bacteriocin precursors in numerous other bacteria. This model describes a domain within SgaB and homologous regions from other proteins, many of which appear to be involved in biosynthesis of secondary metabolites. While some substrates may be intermediates in non-ribosomal peptide syntheses, others are involved in heterocycle-containing bacteriocin biosynthesis, and can be found near SgaC-like (see TIGR03603, cyclodehydratase) and SgaD-like (see TIGR03604, "docking") proteins. Members of this domain family are heterogeneous in length, as many have a partial second copy of the domain represented here. The incomplete second domain scores below the cutoffs to this model in most cases. |
| References | RN [1]
RM PMID:18375757
RT Discovery of a widely distributed toxin biosynthetic gene cluster.
RA Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE
RL Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84. |
| Genome Property | GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM) |
