HMM Summary Page: TIGR03619

Functionprobable F420-dependent oxidoreductase, Rv2161c family
Trusted Cutoff166.90
Domain Trusted Cutoff166.90
Noise Cutoff166.50
Domain Noise Cutoff166.50
Isology Typesubfamily_domain
EC Number1.-.-.-
HMM Length247
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0008150: biological_process biological_process
GO:0016491: oxidoreductase activity molecular_function
AuthorHaft DH
Entry DateJun 11 2008 11:20PM
Last ModifiedFeb 14 2011 3:27PM
CommentCoenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (PF00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria.
ReferencesRN [1] RM PMID:20675471 RT Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria. RA Selengut JD, Haft DH RL J Bacteriol. 2010 Nov;192(21):5788-98.
Genome PropertyGenProp0002: coenzyme F420 utilization (HMM)