|Function||heme uptake protein IsdC|
|Domain Trusted Cutoff||155.85|
|Domain Noise Cutoff||153.85|
|Gene Ontology Term||GO:0020037: heme binding molecular_function|
|Entry Date||Sep 3 2008 11:07AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins . The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, PF05031) domain which confers the ability to bind heme  and a C-terminal SrtB processing signal which targets the protein to the cell wall . IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall.|
RT Demonstration of the iron-regulated surface determinant heme transfer pathway in Staphylococcus aureus.
RA Muryoi N, Tiedemann MT, Pluym M, Cheung J, Heinrichs DE, Stillman MJ
RL J Biol Chem. 2008 Aug 1.
RT The IsdC protein from staphylococcus aureus uses a flexible binding pocket to capture heme.
RA Villareal VA, Pilpa RM, Robson SA, Fadeev EA, Clubb RT
RL J Biol Chem. 2008 Aug 20.
RT Surface protein IsdC and Sortase B are required for heme-iron scavenging of Bacillus anthracis.
RA Maresso AW, Chapa TJ, Schneewind O
RL J Bacteriol. 2006 Dec;188(23):8145-52. Epub 2006 Sep 29.|
|Genome Property||GenProp0828: heme uptake system, NEAT-domain mediated (HMM)|
© J. Craig Venter Institute | Privacy Statement | Data Disclaimer