HMM Summary Page: TIGR03656

Functionheme uptake protein IsdC
Gene SymbolisdC
Trusted Cutoff155.85
Domain Trusted Cutoff155.85
Noise Cutoff153.85
Domain Noise Cutoff153.85
Isology Typeequivalog
HMM Length219
Gene Ontology TermGO:0020037: heme binding molecular_function
AuthorSelengut J
Entry DateSep 3 2008 11:07AM
Last ModifiedFeb 14 2011 3:27PM
CommentIsd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins [1]. The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, PF05031) domain which confers the ability to bind heme [2] and a C-terminal SrtB processing signal which targets the protein to the cell wall [3]. IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall.
ReferencesRN [1] RM PMID:18676371 RT Demonstration of the iron-regulated surface determinant heme transfer pathway in Staphylococcus aureus. RA Muryoi N, Tiedemann MT, Pluym M, Cheung J, Heinrichs DE, Stillman MJ RL J Biol Chem. 2008 Aug 1. RN [2] RM PMID:18715872 RT The IsdC protein from staphylococcus aureus uses a flexible binding pocket to capture heme. RA Villareal VA, Pilpa RM, Robson SA, Fadeev EA, Clubb RT RL J Biol Chem. 2008 Aug 20. RN [3] RM PMID:17012401 RT Surface protein IsdC and Sortase B are required for heme-iron scavenging of Bacillus anthracis. RA Maresso AW, Chapa TJ, Schneewind O RL J Bacteriol. 2006 Dec;188(23):8145-52. Epub 2006 Sep 29.
Genome PropertyGenProp0828: heme uptake system, NEAT-domain mediated (HMM)