|Function||heme uptake protein IsdB|
|Domain Trusted Cutoff||1231.50|
|Domain Noise Cutoff||766.85|
|Gene Ontology Term||GO:0020037: heme binding molecular_function|
|Entry Date||Sep 4 2008 10:19AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins . The IsdB protein is only observed in Staphylococcus and consists of an N-terminal hydrophobic signal sequence, a pair of tandem NEAT (NEAr Transporter, PF05031) domains which confers the ability to bind heme  and a C-terminal sortase processing signal which targets the protein to the cell wall. IsdB is believed to make a direct contact with methemoglobin facilitating transfer of heme to IsdB . The heme is then transferred to other cell wall-bound NEAT domain proteins such as IsdA and IsdC.|
RT Demonstration of the iron-regulated surface determinant heme transfer pathway in Staphylococcus aureus.
RA Muryoi N, Tiedemann MT, Pluym M, Cheung J, Heinrichs DE, Stillman MJ
RL J Biol Chem. 2008 Aug 1.
RT Haem recognition by a Staphylococcus aureus NEAT domain.
RA Grigg JC, Vermeiren CL, Heinrichs DE, Murphy ME
RL Mol Microbiol. 2007 Jan;63(1):139-49.
RT Pathway for heme uptake from human methemoglobin by the iron-regulated surface determinants system of Staphylococcus aureus.
RA Zhu H, Xie G, Liu M, Olson JS, Fabian M, Dooley DM, Lei B
RL J Biol Chem. 2008 Jun 27;283(26):18450-60. Epub 2008 May 8.|
|Genome Property||GenProp0828: heme uptake system, NEAT-domain mediated (HMM)|
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