HMM Summary Page: TIGR03659

Functionheme ABC transporter, heme-binding protein isdE
Gene SymbolisdE
Trusted Cutoff298.65
Domain Trusted Cutoff298.65
Noise Cutoff249.70
Domain Noise Cutoff249.70
Isology Typeequivalog
HMM Length292
AuthorSelengut J
Entry DateSep 4 2008 12:48PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of ABC substrate-binding proteins is observed primarily in close proximity with proteins localized to the cell wall and bearing the NEAT (NEAr Transporter, PF05031) heme-binding domain [1,2]. IsdE has been shown to bind heme and is involved in the process of scavenging heme for the purpose of obtaining iron [3,4].
ReferencesRN [1] RM PMID:18676371 RT Demonstration of the iron-regulated surface determinant heme transfer pathway in Staphylococcus aureus. RA Muryoi N, Tiedemann MT, Pluym M, Cheung J, Heinrichs DE, Stillman MJ RL J Biol Chem. 2008 Aug 1. RN [2] RM PMID:18715872 RT The IsdC protein from staphylococcus aureus uses a flexible binding pocket to capture heme. RA Villareal VA, Pilpa RM, Robson SA, Fadeev EA, Clubb RT RL J Biol Chem. 2008 Aug 20. RN [3] RM PMID:17929943 RT Heme binding properties of Staphylococcus aureus IsdE. RA Pluym M, Vermeiren CL, Mack J, Heinrichs DE, Stillman MJ RL Biochemistry. 2007 Nov 6;46(44):12777-87. Epub 2007 Oct 12. RN [4] RM PMID:17666394 RT Heme coordination by Staphylococcus aureus IsdE. RA Grigg JC, Vermeiren CL, Heinrichs DE, Murphy ME RL J Biol Chem. 2007 Sep 28;282(39):28815-22. Epub 2007 Jul 31.
Genome PropertyGenProp0828: heme uptake system, NEAT-domain mediated (HMM)