|Function||PPOX class probable F420-dependent enzyme, Rv0121 family|
|Domain Trusted Cutoff||119.15|
|Domain Noise Cutoff||77.50|
|Entry Date||Oct 20 2008 8:11AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN.|
RT Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria.
RA Selengut JD, Haft DH
RL J Bacteriol. 2010 Nov;192(21):5788-98.
RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.
RA Haft DH, Paulsen IT, Ward N, Selengut JD
RL BMC Biol. 2006 Aug 24;4:29.|
|Genome Property||GenProp0002: coenzyme F420 utilization (HMM)|
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