| Accession | TIGR03674 |
| Name | fen_arch |
| Function | flap structure-specific endonuclease |
| Gene Symbol | fen |
| Trusted Cutoff | 351.95 |
| Domain Trusted Cutoff | 351.95 |
| Noise Cutoff | 351.80 |
| Domain Noise Cutoff | 351.80 |
| Isology Type | equivalog |
| EC Number | 3.1.-.- |
| HMM Length | 338 |
| Author | Selengut J |
| Entry Date | Oct 22 2008 12:57PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Endonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Has 5'-endo-/exonuclease and 5'-pseudo-Y-endonuclease activities. Cleaves the junction between single and double-stranded regions of flap DNA |
| References | RN [1]
RM PMID:12147694
RT Molecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshii.
RA Matsui E, Musti KV, Abe J, Yamasaki K, Matsui I, Harata K
RL J Biol Chem. 2002 Oct 4;277(40):37840-7. Epub 2002 Jul 29. |
| Genome Property | GenProp0831: archaeal core gene set, exactly 1 per genome (HMM) |
