HMM Summary Page: TIGR03682

Functiondiphthamide biosynthesis enzyme Dph2
Gene Symboldph2
Trusted Cutoff202.80
Domain Trusted Cutoff202.80
Noise Cutoff201.65
Domain Noise Cutoff201.65
Isology Typeequivalog
HMM Length308
AuthorSelengut J, Haft DH
Entry DateNov 4 2008 9:22AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the archaeal protein Dph2, members of the universal archaeal protein family designated arCOG04112 [1]. The chemical function of this protein is analogous to the radical SAM family (PF04055), although the sequence is not homologous. The chemistry involves [4Fe-4S]-aided formation of a 3-amino-3-carboxypropyl radical rather than the canonical 5'-deoxyadenosyl radical of the radical SAM family.
ReferencesRN [1] RM PMID:18042280 RT Clusters of orthologous genes for 41 archaeal genomes and implications for evolutionary genomics of archaea. RA Makarova KS, Sorokin AV, Novichkov PS, Wolf YI, Koonin EV RL Biol Direct. 2007 Nov 27;2:33. RN [2] RM PMID:20559380 RT Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. RA Zhang Y, Zhu X, Torelli AT, Lee M, Dzikovski B, Koralewski RM, Wang E, Freed J, Krebs C, Ealick SE, Lin H RL Nature. 2010 Jun 17;465(7300):891-6.
Genome PropertyGenProp0831: archaeal core gene set, exactly 1 per genome (HMM)