| Accession | TIGR03686 |
| Name | pupylate_PafA |
| Function | proteasome accessory factor PafA |
| Gene Symbol | pafA |
| Trusted Cutoff | 551.30 |
| Domain Trusted Cutoff | 551.30 |
| Noise Cutoff | 429.85 |
| Domain Noise Cutoff | 429.85 |
| Isology Type | equivalog |
| EC Number | 6.3.2.- |
| HMM Length | 457 |
| Mainrole Category | Protein fate |
| Subrole Category | Degradation of proteins, peptides, and glycopeptides |
| Gene Ontology Term | GO:0010498: proteasomal protein catabolic process biological_process |
| | GO:0016879: ligase activity, forming carbon-nitrogen bonds molecular_function |
| | GO:0019941: modification-dependent protein catabolic process biological_process |
| Author | Haft DH |
| Entry Date | Nov 5 2008 9:39AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are PafA (proteasome accessory factor A), a protein shown to regulate steady-state levels of certain proteasome targets in Mycobacterium tuberculosis. Iyer, et al (2008) suggest that PafA is the ligase for Pup, a ubiquitin analog attached to an epsilon-amino group of a Lys side-chain to direct the target to the proteasome. |
| References | RN [1]
RM PMID:17277063
RT Characterization of the proteasome accessory factor (paf) operon in Mycobacterium tuberculosis.
RA Festa RA, Pearce MJ, Darwin KH
RL J Bacteriol. 2007 Apr;189(8):3044-50. |
| Genome Property | GenProp0833: proteasome-targeting modification by pupylation (HMM) |
