| Accession | TIGR03687 |
| Name | pupylate_cterm |
| Function | ubiquitin-like protein Pup |
| Trusted Cutoff | 41.45 |
| Domain Trusted Cutoff | 41.45 |
| Noise Cutoff | 24.80 |
| Domain Noise Cutoff | 24.80 |
| Isology Type | equivalog_domain |
| HMM Length | 33 |
| Mainrole Category | Protein fate |
| Subrole Category | Degradation of proteins, peptides, and glycopeptides |
| Gene Ontology Term | GO:0003674: molecular_function molecular_function |
| | GO:0010498: proteasomal protein catabolic process biological_process |
| | GO:0019941: modification-dependent protein catabolic process biological_process |
| Author | Haft DH |
| Entry Date | Nov 5 2008 10:30AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are Pup, a small protein whose ligation to target proteins steers them toward degradation. This protein family occurs in a number of bacteria, especially Actinobacteria such as Mycobacterium tuberculosis, that possess an archeal-type proteasome. All members of this protein family known during model construction end with the C-terminal motif [FY][VI]QKGG[QE]. Ligation is thought to occur between the C-terminal COOH of Pup and an epsilon-amino group of a Lys on the target protein. The N-terminal half of this protein is poorly conserved and not represented in the seed alignment. |
| References | RN [1]
RM PMID:18832610
RT Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis.
RA Pearce MJ, Mintseris J, Ferreyra J, Gygi SP, Darwin KH
RL Science. 2008 Oct 2. |
| Genome Property | GenProp0833: proteasome-targeting modification by pupylation (HMM) |
