Accession | TIGR03688 |
Name | pupylate_PafA2 |
Function | proteasome accessory factor PafA2 |
Trusted Cutoff | 492.30 |
Domain Trusted Cutoff | 492.30 |
Noise Cutoff | 406.65 |
Domain Noise Cutoff | 406.65 |
Isology Type | equivalog |
EC Number | 6.3.2.- |
HMM Length | 485 |
Mainrole Category | Protein fate |
Subrole Category | Degradation of proteins, peptides, and glycopeptides |
Gene Ontology Term | GO:0010498: proteasomal protein catabolic process biological_process |
| GO:0016879: ligase activity, forming carbon-nitrogen bonds molecular_function |
| GO:0019941: modification-dependent protein catabolic process biological_process |
Author | Haft DH |
Entry Date | Nov 5 2008 11:04AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This protein family is paralogous to (and distinct from) the PafA (proteasome accessory factor) first described in Mycobacterium tuberculosis (see TIGR03686). Members of both this family and TIGR03686 itself tend to cluster with each other, with the ubiquitin analog Pup (TIGR03687) associated with targeting to the proteasome, and with proteasome subunits themselves. |
References | RN [1]
RM PMID:17277063
RT Characterization of the proteasome accessory factor (paf) operon in Mycobacterium tuberculosis.
RA Festa RA, Pearce MJ, Darwin KH
RL J Bacteriol. 2007 Apr;189(8):3044-50.
RN [2]
RM PMID:18832610
RT Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis.
RA Pearce MJ, Mintseris J, Ferreyra J, Gygi SP, Darwin KH
RL Science. 2008 Oct 2. |
Genome Property | GenProp0833: proteasome-targeting modification by pupylation (HMM) |