Accession | TIGR03690 |
Name | 20S_bact_beta |
Function | proteasome, beta subunit |
Gene Symbol | prcB |
Trusted Cutoff | 191.90 |
Domain Trusted Cutoff | 191.90 |
Noise Cutoff | 118.05 |
Domain Noise Cutoff | 118.05 |
Isology Type | equivalog |
EC Number | 3.4.25.1 |
HMM Length | 222 |
Mainrole Category | Protein fate |
Subrole Category | Degradation of proteins, peptides, and glycopeptides |
Gene Ontology Term | GO:0004298: threonine-type endopeptidase activity molecular_function |
| GO:0005839: proteasome core complex cellular_component |
| GO:0010498: proteasomal protein catabolic process biological_process |
Author | Haft DH |
Entry Date | Nov 6 2008 10:05AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Members of this family are the beta subunit of the 20S proteasome as found in Actinobacteria such as Mycobacterium, Rhodococcus, and Streptomyces. In Streptomyces, maturation during proteasome assembly was shown to remove a 53-amino acid propeptide. Most of the length of the propeptide is not included in this model. |
References | RN [1]
RM PMID:9765579
RT The 20S proteasome of Streptomyces coelicolor.
RA Nagy I, Tamura T, Vanderleyden J, Baumeister W, De Mot R
RL J Bacteriol. 1998 Oct;180(20):5448-53.
RN [2]
RM PMID:16468985
RT Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity.
RA Lin G, Hu G, Tsu C, Kunes YZ, Li H, Dick L, Parsons T, Li P, Chen Z, Zwickl P, Weich N, Nathan C
RL Mol Microbiol. 2006 Mar;59(5):1405-16. |
Genome Property | GenProp0834: proteasome, bacterial (HMM) |