HMM Summary Page: TIGR03695

Function2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Gene SymbolmenH
Trusted Cutoff208.55
Domain Trusted Cutoff208.55
Noise Cutoff127.95
Domain Noise Cutoff127.95
Isology Typeequivalog
EC Number4.2.99.20
HMM Length252
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0009234: menaquinone biosynthetic process biological_process
GO:0070205: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity molecular_function
AuthorHaft DH
Entry DateNov 11 2008 4:28PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase.
ReferencesRN [1] RM PMID:18284213 RT Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli. RA Jiang M, Chen X, Guo ZF, Cao Y, Chen M, Guo Z RL Biochemistry. 2008 Mar 18;47(11):3426-34.
Genome PropertyGenProp0058: menaquinone biosynthesis via SEPHCHC (HMM)