| Accession | TIGR03695 |
| Name | menH_SHCHC |
| Function | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase |
| Gene Symbol | menH |
| Trusted Cutoff | 208.55 |
| Domain Trusted Cutoff | 208.55 |
| Noise Cutoff | 127.95 |
| Domain Noise Cutoff | 127.95 |
| Isology Type | equivalog |
| EC Number | 4.2.99.20 |
| HMM Length | 252 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Menaquinone and ubiquinone |
| Gene Ontology Term | GO:0009234: menaquinone biosynthetic process biological_process |
| | GO:0070205: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity molecular_function |
| Author | Haft DH |
| Entry Date | Nov 11 2008 4:28PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. |
| References | RN [1]
RM PMID:18284213
RT Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli.
RA Jiang M, Chen X, Guo ZF, Cao Y, Chen M, Guo Z
RL Biochemistry. 2008 Mar 18;47(11):3426-34. |
| Genome Property | GenProp0058: menaquinone biosynthesis via SEPHCHC (HMM) |
