HMM Summary Page: TIGR03705

Functionpolyphosphate kinase 1
Gene Symbolppk1
Trusted Cutoff465.85
Domain Trusted Cutoff465.85
Noise Cutoff241.75
Domain Noise Cutoff241.75
Isology Typeequivalog
EC Number2.7.4.1
HMM Length673
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryPhosphorus compounds
Gene Ontology TermGO:0006799: polyphosphate biosynthetic process biological_process
GO:0008976: polyphosphate kinase activity molecular_function
GO:0009358: polyphosphate kinase complex cellular_component
AuthorHaft DH
Entry DateJan 22 2009 1:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the enzyme polyphosphate kinase 1 (PPK1). This family is found in many prokaryotes and also in Dictyostelium. Sequences in the seed alignment were taken from prokaryotic consecutive two-gene pairs in which the other gene encodes an exopolyphosphatase. It synthesizes polyphosphate from the terminal phosphate of ATP but not GTP, in contrast to PPK2.
ReferencesRN [1] RM PMID:2164013 RT Polyphosphate kinase from Escherichia coli. Purification and demonstration of a phosphoenzyme intermediate. RA Ahn K, Kornberg A RL J Biol Chem. 1990 Jul 15;265(20):11734-9. RN [2] RM PMID:15520374 RT Inorganic polyphosphate in the origin and survival of species. RA Brown MR, Kornberg A RL Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16085-7.
Genome PropertyGenProp0840: polyphosphate kinase/exopolyphosphatase system (HMM)