HMM Summary Page: TIGR03707

Functionpolyphosphate kinase 2
Gene Symbolppk2
Trusted Cutoff301.80
Domain Trusted Cutoff301.80
Noise Cutoff248.45
Domain Noise Cutoff248.45
Isology Typeequivalog
EC Number2.7.4.1
HMM Length230
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryPhosphorus compounds
Gene Ontology TermGO:0005575: cellular_component cellular_component
GO:0006793: phosphorus metabolic process biological_process
GO:0008976: polyphosphate kinase activity molecular_function
AuthorHaft DH
Entry DateJan 23 2009 2:11PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are designated polyphosphate kinase 2 (PPK2) after the characterized protein in Pseudomonas aeruginosa. This family comprises one of three well-separated clades in the larger family described by Pfam model PF03976. PA0141 from this family has been shown capable of operating in reverse, with GDP preferred (over ADP) as a substrate, producing GTP (or ATP) by transfer of a phosphate residue from polyphosphate. Most species with a member of this family also encode a polyphosphate kinase 1 (PPK1).
ReferencesRN [1] RM PMID:12482933 RT Polyphosphate kinase (PPK2), a potent, polyphosphate-driven generator of GTP. RA Ishige K, Zhang H, Kornberg A RL Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16684-8.
Genome PropertyGenProp0840: polyphosphate kinase/exopolyphosphatase system (HMM)