HMM Summary Page: TIGR03708

Functionpolyphosphate:AMP phosphotransferase
Gene Symbolpap
Trusted Cutoff547.65
Domain Trusted Cutoff547.65
Noise Cutoff459.10
Domain Noise Cutoff459.10
Isology Typeequivalog
EC Number2.7.4.-
HMM Length493
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryPhosphorus compounds
Gene Ontology TermGO:0005575: cellular_component cellular_component
GO:0006797: polyphosphate metabolic process biological_process
GO:0043751: polyphosphate:AMP phosphotransferase activity molecular_function
AuthorHaft DH
Entry DateJan 23 2009 3:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family contain a domain duplication. The characterized member from Acinetobacter johnsonii is polyphosphate:AMP phosphotransferase (PAP), which can transfer the terminal phosphate from poly(P) to AMP, yielding ADP. In the opposite direction, this enzyme can synthesize poly(P). Each domain of this protein family is homologous to polyphosphate kinase, an enzyme that can run in the forward direction to extend a polyphosphate chain with a new terminal phosphate from ATP, or in reverse to make ATP (or GTP) from ADP (or GDP).
ReferencesRN [1] RM PMID:15262957 RT Polyphosphate synthetic activity of polyphosphate:AMP phosphotransferase in Acinetobacter johnsonii 210A. RA Itoh H, Shiba T RL J Bacteriol. 2004 Aug;186(15):5178-81.
Genome PropertyGenProp0840: polyphosphate kinase/exopolyphosphatase system (HMM)