HMM Summary Page: TIGR03715

FunctionKxYKxGKxW signal peptide
Trusted Cutoff18.00
Domain Trusted Cutoff17.60
Noise Cutoff17.00
Domain Noise Cutoff16.00
Isology Typedomain
HMM Length23
AuthorHaft DH
Entry DateFeb 26 2009 2:37PM
Last ModifiedNov 11 2011 4:33PM
CommentThis model describes a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK and PEP-CTERM forms of signal peptide. This domain tends to occur on long, low-complexity (usually Serine-rich and heavily glycosylated) proteins of the Firmicutes, and (as with YSIRK) the majority of these proteins have the LPXTG cell wall-anchoring motif at the C-terminus.
ReferencesRN [1] RM PMID:17369296 RT Glycine residues in the hydrophobic core of the GspB signal sequence route export toward the accessory Sec pathway. RA Bensing BA, Siboo IR, Sullam PM RL J Bacteriol. 2007 May;189(10):3846-54.
Genome PropertyGenProp0844: accessory Sec system for serine-rich glycoprotein transport (HMM-CLUST)
GenProp0845: protein sorting system, KxYKxGKxW class (HMM)