| Accession | TIGR03722 |
| Name | arch_KAE1 |
| Function | universal archaeal protein Kae1 |
| Gene Symbol | kae1 |
| Trusted Cutoff | 430.90 |
| Domain Trusted Cutoff | 430.90 |
| Noise Cutoff | 426.45 |
| Domain Noise Cutoff | 426.45 |
| Isology Type | equivalog_domain |
| HMM Length | 323 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Author | Haft DH |
| Entry Date | Mar 17 2009 5:16PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family represents the archaeal protein Kae1. Its partner Bud32 is fused with it in about half of the known archaeal genomes. The pair, which appears universal in the archaea, corresponds to EKC/KEOPS complex in eukaryotes. A recent characterization of the member from Pyrococcus abyssi, as an iron-binding, atypical DNA-binding protein with an apurinic lyase activity, challenges the common annotation of close homologs as O-sialoglycoprotein endopeptidase. The latter annotation is based on a characterized protein from the bacterium Pasteurella haemolytica. |
| References | RN [1]
RM PMID:17766251
RT An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro.
RA Hecker A, Leulliot N, Gadelle D, Graille M, Justome A, Dorlet P, Brochier C, Quevillon-Cheruel S, Le Cam E, van Tilbeurgh H, Forterre P
RL Nucleic Acids Res. 2007;35(18):6042-51. |
