HMM Summary Page: TIGR03753

Functionbeta-carotene 15,15'-monooxygenase, Brp/Blh family
Trusted Cutoff95.25
Domain Trusted Cutoff95.25
Noise Cutoff58.05
Domain Noise Cutoff58.05
Isology Typesubfamily
EC Number1.14.99.36
HMM Length260
AuthorHaft DH
Entry DateMay 21 2009 9:28AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis integral membrane protein family includes Brp (bacterio-opsin related protein) and Blh (Brp-like protein). Bacteriorhodopsin is a light-driven proton pump with a covalently bound retinal cofactor that appears to be derived beta-carotene. Blh has been shown to cleave beta-carotene to product two all-trans retinal molecules. Mammalian enzymes with similar enzymatic function are not multiple membrane spanning proteins and are not homologous.
ReferencesRN [1] RM PMID:19366683 RT In vitro characterization of a recombinant Blh protein from an uncultured marine bacterium as a beta-carotene 15,15-prime C-dioxygenase. RA Kim YS, Kim NH, Yeom SJ, Kim SW, Oh DK RL J Biol Chem. 2009 Apr 14.
Genome PropertyGenProp0856: bacterio-opsin system (HMM)