HMM Summary Page: TIGR03798

AccessionTIGR03798
Nameocin_TIGR03798
Functionnif11-like leader peptide domain
Trusted Cutoff32.30
Domain Trusted Cutoff32.30
Noise Cutoff29.70
Domain Noise Cutoff29.70
Isology Typesubfamily
HMM Length68
AuthorHaft DH
Entry DateJul 28 2009 1:38PM
Last ModifiedAug 16 2012 4:15PM
CommentThis model describes a conserved, fairly long (about 65 residue) leader peptide region for a family of putative ribosomal natural products (RNP) of small size. Members of the seed alignment (most sequences scoring better than 54 bits to the HMMER 2 model) tend to have the Gly-Gly motif as the last two residues of the matched region. This is a cleavage site for a combination processing/export ABC transporter with a peptidase domain. Members include the prochlorosins, lantipeptides from Prochlorococcus.
ReferencesRN [1] RM PMID:20500830 RT Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family. RA Haft DH, Basu MK, Mitchell DA RL BMC Biol. 2010 May 25;8:70. RN [2] RM PMID:22574919 RT Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. RA Tang W, van der Donk WA RL Biochemistry. 2012 May 29;51(21):4271-9. Epub 2012 May 17.
Genome PropertyGenProp0861: bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group (HMM)
GenProp0861: bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group (HMM)
GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)
GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)
GenProp0861: bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group (HMM)
GenProp0861: bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group (HMM)
GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)
GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)
GenProp0861: bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group (HMM)
GenProp0861: bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group (HMM)
GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)
GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)