|Function||nif11-like leader peptide domain|
|Domain Trusted Cutoff||32.30|
|Domain Noise Cutoff||29.70|
|Entry Date||Jul 28 2009 1:38PM|
|Last Modified||Aug 16 2012 4:15PM|
|Comment||This model describes a conserved, fairly long (about 65 residue) leader peptide region for a family of putative ribosomal natural products (RNP) of small size. Members of the seed alignment (most sequences scoring better than 54 bits to the HMMER 2 model) tend to have the Gly-Gly motif as the last two residues of the matched region. This is a cleavage site for a combination processing/export ABC transporter with a peptidase domain. Members include the prochlorosins, lantipeptides from Prochlorococcus.|
RT Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family.
RA Haft DH, Basu MK, Mitchell DA
RL BMC Biol. 2010 May 25;8:70.
RT Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria.
RA Tang W, van der Donk WA
RL Biochemistry. 2012 May 29;51(21):4271-9. Epub 2012 May 17.|
|Genome Property||GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)|
| ||GenProp0861: bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group (HMM)|
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