HMM Summary Page: TIGR03820

AccessionTIGR03820
Namelys_2_3_AblA
Functionlysine-2,3-aminomutase
Gene SymbolablA
Trusted Cutoff525.40
Domain Trusted Cutoff525.40
Noise Cutoff525.15
Domain Noise Cutoff525.15
Isology Typeequivalog
EC Number5.4.3.2
HMM Length417
AuthorHaft DH
Entry DateSep 9 2009 1:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes lysine-2,3-aminomutase as found along with beta-lysine acetyltransferase in a two-enzyme pathway for making the compatible solute N-epsilon-acetyl-beta-lysine. This compatible solute, or osmolyte, is known to protect a number of methanogenic archaea against salt stress. The trusted cutoff distinguishes a tight clade with essentially full-length homology from additional homologs that are shorter or highly diverged in the C-terminal region. All members of this family have the radical SAM motif CXXXCXXC, while some but not all have a second copy of the motif in the C-terminal region.
ReferencesRN [1] RM PMID:14532061 RT Lysine-2,3-aminomutase and beta-lysine acetyltransferase genes of methanogenic archaea are salt induced and are essential for the biosynthesis of Nepsilon-acetyl-beta-lysine and growth at high salinity. RA Pfluger K, Baumann S, Gottschalk G, Lin W, Santos H, Muller V RL Appl Environ Microbiol. 2003 Oct;69(10):6047-55. RN [2] RM PMID:14532061 RT Lysine-2,3-aminomutase and beta-lysine acetyltransferase genes of methanogenic archaea are salt induced and are essential for the biosynthesis of Nepsilon-acetyl-beta-lysine and growth at high salinity. RA Pfluger K, Baumann S, Gottschalk G, Lin W, Santos H, Muller V RL Appl Environ Microbiol. 2003 Oct;69(10):6047-55.
Genome PropertyGenProp0878: N(epsilon)-acetyl-beta-lysine biosynthesis (HMM)
GenProp0878: N(epsilon)-acetyl-beta-lysine biosynthesis (HMM)
GenProp0878: N(epsilon)-acetyl-beta-lysine biosynthesis (HMM)
GenProp0878: N(epsilon)-acetyl-beta-lysine biosynthesis (HMM)
GenProp0878: N(epsilon)-acetyl-beta-lysine biosynthesis (HMM)
GenProp0878: N(epsilon)-acetyl-beta-lysine biosynthesis (HMM)