HMM Summary Page: TIGR03827

Functionputative beta-lysine N-acetyltransferase
Gene SymbolablB
Trusted Cutoff205.10
Domain Trusted Cutoff205.10
Noise Cutoff107.00
Domain Noise Cutoff107.00
Isology Typeequivalog
EC Number2.3.1.-
HMM Length266
AuthorHaft DH
Entry DateSep 11 2009 10:59AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are GNAT family acetyltransferases, based on a seed alignment in which every member is associated with a lysine 2,3-aminomutase family protein, usually as the adjacent gene. This family includes AblB, the enzyme beta-lysine acetyltransferase that completes the two-step synthesis of the osmolyte (compatible solute) N-epsilon-acetyl-beta-lysine; all members of the family may have this function. Note that N-epsilon-acetyl-beta-lysine has been observed only in methanogenic archaea (e.g. Methanosarcina) but that this model, paired with TIGR03820, suggests a much broader distribution.
ReferencesRN [1] RM PMID:14532061 RT Lysine-2,3-aminomutase and beta-lysine acetyltransferase genes of methanogenic archaea are salt induced and are essential for the biosynthesis of Nepsilon-acetyl-beta-lysine and growth at high salinity. RA Pfluger K, Baumann S, Gottschalk G, Lin W, Santos H, Muller V RL Appl Environ Microbiol. 2003 Oct;69(10):6047-55.
Genome PropertyGenProp0878: N(epsilon)-acetyl-beta-lysine biosynthesis (HMM)