| Accession | TIGR03827 |
| Name | GNAT_ablB |
| Function | putative beta-lysine N-acetyltransferase |
| Gene Symbol | ablB |
| Trusted Cutoff | 205.10 |
| Domain Trusted Cutoff | 205.10 |
| Noise Cutoff | 107.00 |
| Domain Noise Cutoff | 107.00 |
| Isology Type | equivalog |
| EC Number | 2.3.1.- |
| HMM Length | 266 |
| Author | Haft DH |
| Entry Date | Sep 11 2009 10:59AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are GNAT family acetyltransferases, based on a seed alignment in which every member is associated with a lysine 2,3-aminomutase family protein, usually as the adjacent gene. This family includes AblB, the enzyme beta-lysine acetyltransferase that completes the two-step synthesis of the osmolyte (compatible solute) N-epsilon-acetyl-beta-lysine; all members of the family may have this function. Note that N-epsilon-acetyl-beta-lysine has been observed only in methanogenic archaea (e.g. Methanosarcina) but that this model, paired with TIGR03820, suggests a much broader distribution. |
| References | RN [1]
RM PMID:14532061
RT Lysine-2,3-aminomutase and beta-lysine acetyltransferase genes of methanogenic archaea are salt induced and are essential for the biosynthesis of Nepsilon-acetyl-beta-lysine and growth at high salinity.
RA Pfluger K, Baumann S, Gottschalk G, Lin W, Santos H, Muller V
RL Appl Environ Microbiol. 2003 Oct;69(10):6047-55. |
| Genome Property | GenProp0878: N(epsilon)-acetyl-beta-lysine biosynthesis (HMM) |
