HMM Summary Page: TIGR03857

Functionprobable F420-dependent oxidoreductase, MSMEG_2249 family
Trusted Cutoff218.40
Domain Trusted Cutoff218.40
Noise Cutoff216.85
Domain Noise Cutoff216.85
Isology Typehypoth_equivalog
HMM Length329
AuthorHaft DH
Entry DateOct 9 2009 4:24PM
Last ModifiedFeb 14 2011 3:27PM
CommentCoenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (PF00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a distinctive subfamily, found only in F420-biosynthesizing members of the Actinobacteria of the bacterial luciferase-like monooxygenase (LLM) superfamily.
ReferencesRN [1] RM PMID:20675471 RT Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria. RA Selengut JD, Haft DH RL J Bacteriol. 2010 Nov;192(21):5788-98.
Genome PropertyGenProp0002: coenzyme F420 utilization (HMM)