HMM Summary Page: TIGR03913

FunctionY_X(10)_GDL-associated radical SAM protein
Trusted Cutoff591.75
Domain Trusted Cutoff591.75
Noise Cutoff591.45
Domain Noise Cutoff591.45
Isology Typehypoth_equivalog
HMM Length477
AuthorHaft DH
Entry DateJan 6 2010 4:57PM
Last ModifiedJun 9 2011 9:51AM
CommentThis narrowly distributed protein family contains an N-terminal radical SAM domain. It occurs in Pseudomonas fluorescens Pf0-1, Ralstonia solanacearum, and numerous species and strains of Burkholderia. Members always occur next to a trio of three mutually homologous genes, all of which contain the domain PF08898 as the whole of the protein (about 60 amino acids) or as the C-terminal domain. The function is unknown, but the fact that all phylogenetically correlated proteins are mutually homologous with prominent invariant motifs (an invariant tyrosine and a GDL motif) and as small as 60 amino acids suggests that post-translational modification of PF08898 domain-containing proteins may be its function. This view is supported by closer homology to the PqqE radical SAM protein involved in PQQ biosynthesis from the PqqA precursor peptide than to other characterized radical SAM proteins.
ReferencesRN [1] RM PMID:21478363 RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational mo dification. RA Haft DH, Basu MK RL J Bacteriol. 2011 Jun;193(11):2745-55.
Genome PropertyGenProp0920: radical SAM Y_X(10)_GDL system (HMM)