HMM Summary Page: TIGR03937

Functionpoly-beta-1,6 N-acetyl-D-glucosamine synthase
Gene SymbolpgaC
Trusted Cutoff422.30
Domain Trusted Cutoff422.30
Noise Cutoff206.80
Domain Noise Cutoff206.80
Isology Typeequivalog
EC Number2.4.1.-
HMM Length407
AuthorHaft DH
Entry DateFeb 11 2010 9:48PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are biofilm-forming enzymes that polymerize N-acetyl-D-glucosamine residues in beta(1,6) linkage. One named members is IcaA (intercellular adhesin protein A), an enzyme that acts (with aid of subunit IcaD) in Polysaccharide Intercellular Adhesin (PIA) biosynthesis in Staphylococcus epidermis). The homologous member in E. coli is designated PgaC. Members are often encoded next to a polysaccharide deacetylase and involved in biofilm formation. Note that chitin, although also made from N-acetylglucosamine, is formed with beta-1,4 linkages.
ReferencesRN [1] RM PMID:15090514 RT The pgaABCD locus of Escherichia coli promotes the synthesis of a polysaccharide adhesin required for biofilm formation. RA Wang X, Preston JF 3rd, Romeo T RL J Bacteriol. 2004 May;186(9):2724-34.
Genome PropertyGenProp0907: poly-beta-1,6 N-acetyl-D-glucosamine system, PgaABCD type (HMM)