HMM Summary Page: TIGR03938

Functionpoly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB
Gene SymbolpgaB
Trusted Cutoff321.90
Domain Trusted Cutoff321.90
Noise Cutoff168.65
Domain Noise Cutoff168.65
Isology Typeequivalog
EC Number3.5.1.-
HMM Length618
AuthorHaft DH
Entry DateFeb 12 2010 2:50PM
Last ModifiedFeb 14 2011 3:27PM
CommentTwo well-characterized systems produce polysaccharide based on N-acetyl-D-glucosamine in straight chains with beta-1,6 linkages. These are encoded by the icaADBC operon in Staphylococcus species, where the system is designated polysaccharide intercellular adhesin (PIA), and the pgaABCD operon in Gram-negative bacteria such as E. coli. Both systems include a putative polysaccharide deacetylase. The PgaB protein, described here, contains an additional domain lacking from its Gram-positive counterpart IcaB (TIGR03933). Deacetylation by this protein appears necessary to allow export through the porin PgaA
ReferencesRN [1] RM PMID:18359807 RT Roles of pgaABCD genes in synthesis, modification, and export of the Escherichia coli biofilm adhesin poly-beta-1,6-N-acetyl-D-glucosamine. RA Itoh Y, Rice JD, Goller C, Pannuri A, Taylor J, Meisner J, Beveridge TJ, Preston JF 3rd, Romeo T RL J Bacteriol. 2008 May;190(10):3670-80. Epub 2008 Mar 21.
Genome PropertyGenProp0907: poly-beta-1,6 N-acetyl-D-glucosamine system, PgaABCD type (HMM)