HMM Summary Page: TIGR03939

Functionpoly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA
Gene SymbolpgaA
Trusted Cutoff366.65
Domain Trusted Cutoff366.65
Noise Cutoff288.00
Domain Noise Cutoff288.00
Isology Typeequivalog
HMM Length800
AuthorHaft DH
Entry DateFeb 12 2010 3:11PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the poly-beta-1,6 N-acetyl-D-glucosamine (PGA) export porin PgaA of Gram-negative bacteria. There is no counterpart in the poly-beta-1,6 N-acetyl-D-glucosamine biosynthesis systems of Gram-positive bacteria such as Staphylococcus epidermidis. The PGA polysaccharide adhesin is a critical determinant of biofilm formation. The conserved C-terminal domain of this outer membrane protein is preceded by a variable number of TPR repeats.
ReferencesRN [1] RM PMID:15090514 RT The pgaABCD locus of Escherichia coli promotes the synthesis of a polysaccharide adhesin required for biofilm formation. RA Wang X, Preston JF 3rd, Romeo T RL J Bacteriol. 2004 May;186(9):2724-34.
Genome PropertyGenProp0907: poly-beta-1,6 N-acetyl-D-glucosamine system, PgaABCD type (HMM)