HMM Summary Page: TIGR03958

Function5,10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdC
Gene SymbolhmdC
Trusted Cutoff407.00
Domain Trusted Cutoff407.00
Noise Cutoff406.85
Domain Noise Cutoff406.85
Isology Typeequivalog
HMM Length505
AuthorHaft DH
Entry DateMar 12 2010 11:03AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are HmdC, whose gene regularly occurs in the context of genes for HmdA (5,10-methenyltetrahydromethanopterin hydrogenase) and the radical SAM protein HmdB involved in biosynthesis of the HmdA cofactor. Bioinformatics suggests this protein, a homolog of eukaryotic fibrillarin, may be involved in biosynthesis of the guanylyl pyridinol cofactor in HmdA.
ReferencesRN [1] RM PMID:19897660 RT Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor. RA McGlynn SE, Boyd ES, Shepard EM, Lange RK, Gerlach R, Broderick JB, Peters JW RL J Bacteriol. 2010 Jan;192(2):595-8. Epub 2009 Nov 6.
Genome PropertyGenProp0915: hydrogenase, mono-iron type (HMM)