HMM Summary Page: TIGR03972
Accession | TIGR03972 |
Name | rSAM_TYW1 |
Function | wyosine biosynthesis protein TYW1 |
Gene Symbol | twy1 |
Trusted Cutoff | 317.95 |
Domain Trusted Cutoff | 317.95 |
Noise Cutoff | 315.95 |
Domain Noise Cutoff | 315.95 |
Isology Type | equivalog |
HMM Length | 297 |
Author | Haft DH |
Entry Date | Mar 24 2010 4:22PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Members of this protein family are the archaeal protein TWY1, a radical SAM protein that catalyzes the second step in creating the wye-bases, wyosine and derivatives such as wybutosine, for tRNA base modification. |
References | RN [1] RM PMID:17881823 RT Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis. RA Goto-Ito S, Ishii R, Ito T, Shibata R, Fusatomi E, Sekine SI, Bessho Y, Yokoyama S RL Acta Crystallogr D Biol Crystallogr. 2007 Oct;63(Pt 10):1059-68. RN [2] RM PMID:17727881 RT Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA. RA Suzuki Y, Noma A, Suzuki T, Senda M, Senda T, Ishitani R, Nureki O RL J Mol Biol. 2007 Oct 5;372(5):1204-14. |