HMM Summary Page: TIGR03974

FunctionSCIFF radical SAM maturase
Gene SymbolscfB
Trusted Cutoff425.00
Domain Trusted Cutoff425.00
Noise Cutoff380.00
Domain Noise Cutoff380.00
Isology Typehypoth_equivalog
HMM Length451
AuthorHaft DH
Entry DateMar 25 2010 12:58PM
Last ModifiedJul 5 2011 12:49PM
CommentMembers of this protein family are predicted radical SAM enzymes universally associated with Six Cysteines in Forty-Five protein, or SCIFF (family TIGR03973), a predicted ribosomal natural product precursor that is nearly universal in the class Clostridia. Similarity of this family to radical SAM maturases (PqqE and subtilosin A maturase) found in the vicinity of other peptide precursors suggests this protein is the SCIFF radical SAM maturase.
ReferencesRN [1] RM PMID:21478363 RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification. RA Haft DH, Basu MK RL J Bacteriol. 2011 Jun;193(11):2745-55.
Genome PropertyGenProp0919: SCIFF/radical SAM Clostridial gene pair (HMM)