HMM Summary Page: TIGR03975

Functionribosomal peptide maturation radical SAM protein 1
Trusted Cutoff281.85
Domain Trusted Cutoff281.85
Noise Cutoff255.45
Domain Noise Cutoff255.45
Isology Typesubfamily
HMM Length606
AuthorHaft DH
Entry DateMar 25 2010 2:35PM
Last ModifiedMar 10 2014 6:26PM
CommentModels TIGR03793 and TIGR03798 describe bacteriocin precursor families to occur often in large paralogous families and are subject to various modifications, including by LanM family lantibiotic synthases and by cyclodehydratases. This model represents a radical SAM protein family that regularly occurs in the context of these bacteriocins, and may occur where other familiar peptide modification enzymes are absent.
ReferencesRN [1] RM PMID:20500830 RT Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family. RA Haft DH, Basu MK, Mitchell DA RL BMC Biol. 2010 May 25;8:70. doi: 10.1186/1741-7007-8-70. RN [2] RM PMID:22983711 RT Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides. RA Freeman MF, Gurgui C, Helf MJ, Morinaka BI, Uria AR, Oldham NJ, Sahl HG, Matsunaga S, Piel J RL Science. 2012 Oct 19;338(6105):387-90. doi: 10.1126/science.1226121.
Genome PropertyGenProp0861: bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group (HMM)