HMM Summary Page: TIGR03979

FunctionHis-Xaa-Ser repeat protein HxsA
Gene SymbolhxsA
Trusted Cutoff121.65
Domain Trusted Cutoff121.65
Noise Cutoff63.80
Domain Noise Cutoff63.80
Isology Typehypoth_equivalog
HMM Length190
AuthorHaft DH
Entry DateApr 4 2010 2:07PM
Last ModifiedJun 9 2011 9:49AM
CommentMembers of this protein share two defining regions. One is a histidine/serine-rich cluster, typically H-R-S-H-S-S-H-R-S-H-S-S-H. Members are found always in the context of a pair of radical SAM proteins, HxsB and HxsC, and a fourth protein HxsD. The system is predicted to perform peptide modifications, likely in the His-Xaa-Ser region, to produce some uncharacterized natural product.
ReferencesDR PFAM; PF01471; Putative peptidoglycan binding domain RN [1] RM PMID:21478363 RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational mo dification. RA Haft DH, Basu MK RL J Bacteriol. 2011 Jun;193(11):2745-55.
Genome PropertyGenProp0921: radical SAM pair and His-Xaa-Ser repeats peptide (HMM)