|Function||NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family|
|Domain Trusted Cutoff||440.00|
|Domain Noise Cutoff||360.00|
|Entry Date||Apr 19 2010 4:18PM|
|Last Modified||Apr 28 2014 11:57AM|
|Comment||This HMM describes a clade within the family PF00107 of zinc-binding dehydrogenases. The family PF00107 contains class III alcohol dehydrogenases, including enzymes designated S-(hydroxymethyl)glutathione dehydrogenase and NAD/mycothiol-dependent formaldehyde dehydrogenase. Members of the current family occur only in species that contain the very small protein mycofactocin (TIGR03969), a possible cofactor precursor, and radical SAM protein TIGR03962. We name this family for Rxyl_3153, where the lone member of the family co-clusters with these markers in Rubrobacter xylanophilus.|
RT Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners.
RA Haft DH
RL BMC Genomics. 2011 Jan 11;12(1):21.
RT Nicotinoprotein (NADH-containing) alcohol dehydrogenase from Rhodococcus erythropolis DSM 1069: an efficient catalyst for coenzyme-independent oxidation of a broad spectrum of alcohols and the interconversion of alcohols and aldehydes.
RA Schenkels P, Duine JA
RL Microbiology. 2000 Apr;146 ( Pt 4):775-85.|
|Genome Property||GenProp0917: mycofactocin system (HMM)|
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