|Function||UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase|
|Domain Trusted Cutoff||225.30|
|Domain Noise Cutoff||223.50|
|EC Number||18.104.22.168 22.214.171.124|
|Entry Date||Apr 21 2010 1:31PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||The MJ_1101 protein from Methanococcus jannaschii has been characterized as the GlmU enzyme catalyzing the final two steps of UDP-GlcNAc biosynthesis . Homologs of this enzyme are identified in a number of bacterial organisms and modeled here. A number of these are observed in proximity to the GlmS and GlmM genes, and phylogenetic profiling by PPP  identifies the LEPBI_I0518 gene in Leptospira biflexa as a likely Glm-system candidate. Multiple sequence alignments of these bacterial homologs with their archaeal counterparts reveals significant structural differences, necessitating the construction of separate models.|
RT Acetamido sugar biosynthesis in the Euryarchaea.
RA Namboori SC, Graham DE
RL J Bacteriol. 2008 Apr;190(8):2987-96. Epub 2008 Feb 8.
RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.
RA Haft DH, Paulsen IT, Ward N, Selengut JD
RL BMC Biol. 2006 Aug 24;4:29.|
|Genome Property||GenProp0750: UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate (HMM)|
© J. Craig Venter Institute | Privacy Statement | Data Disclaimer