HMM Summary Page: TIGR03999

FunctionN-acetyl-alpha-D-glucosaminyl L-malate synthase BshA
Gene SymbolbshA
Trusted Cutoff273.70
Domain Trusted Cutoff273.70
Noise Cutoff173.85
Domain Noise Cutoff173.85
Isology Typeequivalog
EC Number2.4.1.-
HMM Length375
AuthorHaft DH
Entry DateMay 20 2010 4:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are BshA, a glycosyltransferase required for bacillithiol biosynthesis. This enzyme combines UDP-GlcNAc and L-malate to form N-acetyl-alpha-D-glucosaminyl L-malate synthase. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes.
ReferencesRN [1] RM PMID:20308541 RT Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. RA Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD RL Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6482-6.
Genome PropertyGenProp0927: bacillithiol biosynthesis (HMM)