HMM Summary Page: TIGR04011

Functionpoly-gamma-glutamate biosynthesis protein PgsC
Gene SymbolpgsC
Trusted Cutoff96.45
Domain Trusted Cutoff96.45
Noise Cutoff66.30
Domain Noise Cutoff66.30
Isology Typeequivalog
EC Number6.3.2.-
HMM Length132
AuthorHaft DH
Entry DateJun 3 2010 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentOf four genes commonly found to be involved in biosynthesis and export of poly-gamma-glutamate, pgsB(capB) and pgsC(capC) are found to be involved in the synthesis per se. Members of this family are designated PgsC, covering both cases in which the poly-gamma-glutamate is secreted and those in which it is retained to form capsular material. PgsC binds tightly to PgsB, which has been shown to have poly-gamma-glutamate activity.
ReferencesRN [1] RM PMID:19483793 RT Fusobacterium nucleatum, the first Gram-negative bacterium demonstrated to produce polyglutamate. RA Candela T, Moya M, Haustant M, Fouet A RL Can J Microbiol. 2009 May;55(5):627-32.
Genome PropertyGenProp0822: poly(gamma-glutamic acid) biosynthesis (HMM)