|Function||PPOX class F420-dependent enzyme, MSMEG_5819/OxyR family|
|Domain Trusted Cutoff||85.60|
|Domain Noise Cutoff||61.50|
|Entry Date||Jun 17 2010 3:55PM|
|Last Modified||Mar 16 2014 3:46PM|
|Comment||A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. This subfamily within the PPOX family occurs in at least 19 distinct species of F420 producers and is likely to bind F420 rather than FMN. The member OxyR was shown to use F420 to catalyze a C5a-C11a reduction in oxytetracycline biosynthesis.|
RT Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria.
RA Selengut JD, Haft DH
RL J Bacteriol. 2010 Nov;192(21):5788-98.
RT Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis.
RA Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y
RL J Am Chem Soc. 2013 May 15;135(19):7138-41. doi: 10.1021/ja403516u.|
|Genome Property||GenProp0002: coenzyme F420 utilization (HMM)|
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