HMM Summary Page: TIGR04023

FunctionPPOX class F420-dependent enzyme, MSMEG_5819/OxyR family
Trusted Cutoff85.60
Domain Trusted Cutoff85.60
Noise Cutoff61.50
Domain Noise Cutoff61.50
Isology Typesubfamily
EC Number1.-.-.-
HMM Length115
AuthorHaft DH
Entry DateJun 17 2010 3:55PM
Last ModifiedMar 16 2014 3:46PM
CommentA Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. This subfamily within the PPOX family occurs in at least 19 distinct species of F420 producers and is likely to bind F420 rather than FMN. The member OxyR was shown to use F420 to catalyze a C5a-C11a reduction in oxytetracycline biosynthesis.
ReferencesRN [1] RM PMID:20675471 RT Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria. RA Selengut JD, Haft DH RL J Bacteriol. 2010 Nov;192(21):5788-98. RN [2] RM PMID:23621493 RT Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis. RA Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y RL J Am Chem Soc. 2013 May 15;135(19):7138-41. doi: 10.1021/ja403516u.
Genome PropertyGenProp0002: coenzyme F420 utilization (HMM)