HMM Summary Page: TIGR04068

FunctionCys-rich peptide radical SAM maturase CcpM
Gene SymbolccpM
Trusted Cutoff500.00
Domain Trusted Cutoff500.00
Noise Cutoff375.00
Domain Noise Cutoff375.00
Isology Typeequivalog
HMM Length462
AuthorHaft DH
Entry DateOct 5 2010 3:26PM
Last ModifiedJul 11 2011 8:06AM
CommentMembers of this family are radical SAM enzymes that occur next to clostridial Cys-rich predicted bacteriocin (or other class of ribosomal natural product) precursors (see families TIGR04065 and TIGR04067). They include a TIGR04085 C-terminal additional 4Fe4S cluster-binding domain that is associated with peptide modification by radical SAM enzymes, and they are proposed to be ribosomal natural product maturases. The gene symbol ccpM is assigned, for Clostridial Cys-rich Peptide Maturase.
ReferencesRN [1] RM PMID:21478363 RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational mo dification. RA Haft DH, Basu MK RL J Bacteriol. 2011 Jun;193(11):2745-55.
Genome PropertyGenProp0945: radical SAM maturase bacteriocin system, CLI_3235 type (HMM)