HMM Summary Page: TIGR04081

Functionradical SAM modification target peptide, selenobiotic family
Trusted Cutoff32.00
Domain Trusted Cutoff32.00
Noise Cutoff28.00
Domain Noise Cutoff28.00
Isology Typesubfamily
HMM Length37
AuthorHaft DH
Entry DateNov 1 2010 1:45PM
Last ModifiedJun 9 2011 10:19AM
CommentMembers of this protein family are small peptides found in the vicinity of a peptide modification-type radical SAM protein family. Multiple members of this protein family occur in species with a selenocysteine incorporation systems and have a TGA stop codon at position that aligns with cysteine residues from other homologs. This finding strongly suggests that GSU_1558 and similar members of the family are selenopeptides. The selenocysteine insertion sequence (SECIS) finder bSECISearch finds two homologous SECIS elements for two TGA codons in the extension of GSU_1558. Meanwhile, the pairing with the radical SAM enzyme suggests additional modification.
ReferencesRN [1] RM PMID:21478363 RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification. RA Haft DH, Basu MK RL J Bacteriol. 2011 Jun;193(11):2745-55.
Genome PropertyGenProp0956: radical SAM maturase/selenobacteriocin system (HMM)