HMM Summary Page: TIGR04158
| Accession | TIGR04158 |
| Name | rSAM_MIA_synth |
| Function | 3-methyl-2-indolic acid synthase |
| Gene Symbol | nocL |
| Trusted Cutoff | 400.00 |
| Domain Trusted Cutoff | 400.00 |
| Noise Cutoff | 260.00 |
| Domain Noise Cutoff | 260.00 |
| Isology Type | equivalog |
| EC Number | 4.1.-.- |
| HMM Length | 368 |
| Author | Haft DH |
| Entry Date | Apr 27 2011 2:25PM |
| Last Modified | Apr 27 2011 2:29PM |
| Comment | Members are a radical SAM enzyme that converts L-Trp to 3-methyl-2-indolic acid synthase through a complex rearrangement. This enzyme is closest to ThiH, which also does a complex rearrangement, among other characterized radical SAM enzymes. |
| References | RN [1] RM PMID:21454624 RT Characterization of NocL involved in thiopeptide nocathiacin I biosynthesis: A [4Fe-4S] cluster and the catalysis of a radical S-adenosylmethionine enzyme. RA Zhang Q, Chen D, Lin J, Liao R, Tong W, Xu Z, Liu W RL J Biol Chem. 2011 Mar 29. RN [2] RM PMID:21240261 RT Radical-mediated enzymatic carbon chain fragmentation-recombination. RA Zhang Q, Li Y, Chen D, Yu Y, Duan L, Shen B, Liu W RL Nat Chem Biol. 2011 Mar;7(3):154-60. doi: 10.1038/nchembio.512. |