HMM Summary Page: TIGR04196

Functionglycopeptide, sublancin family
Gene SymbolsunA
Trusted Cutoff40.00
Domain Trusted Cutoff40.00
Noise Cutoff33.00
Domain Noise Cutoff33.00
Isology Typesubfamily
HMM Length80
AuthorHaft DH
Entry DateAug 18 2011 10:35AM
Last ModifiedAug 18 2011 10:55AM
CommentMembers of this family, including sublancin, are post-ribosomal natural products (PRNP) with an S-linked glycosylation. Sublancin itself also has two disulfide bonds. A related gene cluster in Bacillus cereus E33L includes the four Cys involved in the disulfide cluster but lacks the region with the glycosylated Cys. These score ~ 27 by this HMMER3 model and are excluded.
ReferencesRN [1] RM PMID:21196935 RT Sublancin is not a lantibiotic but an S-linked glycopeptide. RA Oman TJ, Boettcher JM, Wang H, Okalibe XN, van der Donk WA RL Nat Chem Biol. 2011 Feb;7(2):78-80.
Genome PropertyGenProp1003: cysteine S-glycopeptide biosynthesis, sublancin family (HMM)