HMM Summary Page: TIGR04220

Functioncyanobactin biosynthesis protein, PatB/AcyB/McaB family
Trusted Cutoff55.00
Domain Trusted Cutoff55.00
Noise Cutoff33.00
Domain Noise Cutoff25.00
Isology Typehypoth_equivalog
HMM Length61
AuthorHaft DH
Entry DateOct 27 2011 10:39AM
Last ModifiedOct 27 2011 10:52AM
CommentMembers of this protein family are small (~ 80 amino acids) and occur in biosynthesis clusters for cyanobactins, a type of ribosomal natural product, thiazole/oxazole-modified microcin (TOMM). The function of this protein family is unknown, and the recognized cyanobactin precursors (e.g. microcyclamides and patellamides) are encoded by a different protein (see TIGR03678). In this protein family, however, a core region of about 62 amino acids (modeled) is followed by a hypervariable region of 5 to 23 amino acids, with hallmarks of possible cyclodehydratase modification sites. The hallmarks include Cys residues flanked by Gly, and variable length Ser-rich tripeptide repeats. Further, members of this family were shown dispensible for patellamide biosynthesis, and two may occur in a cluster. Therefore, this family may represent a precursor of another type of ribosomal natural product.
ReferencesRN [1] RM PMID:18245249 RT Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa. RA Ziemert N, Ishida K, Quillardet P, Bouchier C, Hertweck C, de Marsac NT, Dittmann E RL Appl Environ Microbiol. 2008 Mar;74(6):1791-7. RN [2] RM PMID:20008171 RT Highly diverse cyanobactins in strains of the genus Anabaena. RA Leikoski N, Fewer DP, Jokela J, Wahlsten M, Rouhiainen L, Sivonen K RL Appl Environ Microbiol. 2010 Feb;76(3):701-9.
Genome PropertyGenProp1083: cyanobactin-like ribosomal natural product biosynthesis (HMM)