|Function||cyanobactin biosynthesis protein, PatB/AcyB/McaB family|
|Domain Trusted Cutoff||55.00|
|Domain Noise Cutoff||25.00|
|Entry Date||Oct 27 2011 10:39AM|
|Last Modified||Oct 27 2011 10:52AM|
|Comment||Members of this protein family are small (~ 80 amino acids) and occur in biosynthesis clusters for cyanobactins, a type of ribosomal natural product, thiazole/oxazole-modified microcin (TOMM). The function of this protein family is unknown, and the recognized cyanobactin precursors (e.g. microcyclamides and patellamides) are encoded by a different protein (see TIGR03678). In this protein family, however, a core region of about 62 amino acids (modeled) is followed by a hypervariable region of 5 to 23 amino acids, with hallmarks of possible cyclodehydratase modification sites. The hallmarks include Cys residues flanked by Gly, and variable length Ser-rich tripeptide repeats. Further, members of this family were shown dispensible for patellamide biosynthesis, and two may occur in a cluster. Therefore, this family may represent a precursor of another type of ribosomal natural product.|
RT Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa.
RA Ziemert N, Ishida K, Quillardet P, Bouchier C, Hertweck C, de Marsac NT, Dittmann E
RL Appl Environ Microbiol. 2008 Mar;74(6):1791-7.
RT Highly diverse cyanobactins in strains of the genus Anabaena.
RA Leikoski N, Fewer DP, Jokela J, Wahlsten M, Rouhiainen L, Sivonen K
RL Appl Environ Microbiol. 2010 Feb;76(3):701-9.|
|Genome Property||GenProp1083: cyanobactin-like ribosomal natural product biosynthesis (HMM)|
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