HMM Summary Page: TIGR04223

Functioncyclic lactone autoinducer peptide
Trusted Cutoff19.00
Domain Trusted Cutoff19.00
Noise Cutoff16.80
Domain Noise Cutoff16.00
Isology Typesubfamily
HMM Length38
AuthorHaft DH
Entry DateNov 10 2011 11:29AM
Last ModifiedFeb 10 2012 10:37AM
CommentMembers of this family of short peptides are precursors to thiolactone (unless Cys is replaced by Ser) cyclic autoinducer peptides, used in quorum-sensing systems in Gram-positive bacteria. The best characterized is the AgrD precursor, processed by the AgrB protein. Nearby proteins regularly encountered include a histidine kinase and a response regulator. This model is related to PF05931 but is newer and currently broader in scope.