Accession | TIGR04224 |
Name | ser_adhes_Nterm |
Function | serine-rich repeat adhesion glycoprotein |
Trusted Cutoff | 25.00 |
Domain Trusted Cutoff | 25.00 |
Noise Cutoff | 23.00 |
Domain Noise Cutoff | 15.00 |
Isology Type | equivalog_domain |
HMM Length | 50 |
Author | Haft DH |
Entry Date | Nov 11 2011 2:30PM |
Last Modified | Nov 11 2011 2:50PM |
Comment | This HMM describes a definitive conserved N-terminal domain shared by Streptococcal serine-rich adhesion glycoproteins. These highly repetitive proteins may exceed 4000 amino acids in length, consisting largely of long regions in which every second amino acid is Ser. Members of this family, if sequenced completely and assigned the correct start site, begin with a KxYKxGKxW motif region (see TIGR03715) and end with an LPXTG motif region (see TIGR01167). Members are exported by the accessory secretory system (SecA2 and SecY2). They are highly variable among the Streptococci and may help determine host ranges for pathogenesis. |
References | RN [1]
RM PMID:20562303
RT Transport of preproteins by the accessory Sec system requires a specific domain adjacent to the signal peptide.
RA Bensing BA, Sullam PM
RL J Bacteriol. 2010 Aug;192(16):4223-32. |
Genome Property | GenProp0844: accessory Sec system for serine-rich glycoprotein transport (HMM) |