HMM Summary Page: TIGR04266

FunctionNDMA-dependent methanol dehydrogenase
Gene Symbolmdo
Trusted Cutoff625.00
Domain Trusted Cutoff625.00
Noise Cutoff400.00
Domain Noise Cutoff400.00
Isology Typeequivalog
EC Number1.1.99.37
HMM Length420
AuthorHaft DH
Entry DateJan 16 2012 9:35AM
Last ModifiedJan 16 2012 9:58AM
CommentMembers of this family belong to the iron-dependent alcohol dehydrogenase family (see PF00465). The NADP(H) cofactor is bound too tightly for exchange (although non-convalently), so enzymatic activity depends on a second substrate or electron carrier. The radical SAM-modified natural product mycofactocin is proposed to fill this role.
ReferencesRN [1] RM PMID:8449887 RT Electron microscopic analysis and structural characterization of novel NADP(H)-containing methanol: N,N'-dimethyl-4-nitrosoaniline oxidoreductases from the gram-positive methylotrophic bacteria Amycolatopsis methanolica and Mycobacterium gastri MB19. RA Bystrykh LV, Vonck J, van Bruggen EF, van Beeumen J, Samyn B, Govorukhina NI, Arfman N, Duine JA, Dijkhuizen L RL J Bacteriol. 1993 Mar;175(6):1814-22. RN [2] RM PMID:21223593 RT Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners. RA Haft DH RL BMC Genomics. 2011 Jan 11;12:21.
Genome PropertyGenProp0917: mycofactocin system (HMM)