HMM Summary Page: TIGR04271

AccessionTIGR04271
NameThiI_C_thiazole
Functionthiazole biosynthesis domain
Gene SymbolthiI
Trusted Cutoff70.00
Domain Trusted Cutoff70.00
Noise Cutoff55.00
Domain Noise Cutoff40.00
Isology Typeequivalog_domain
HMM Length101
AuthorHaft DH
Entry DateJan 25 2012 11:58AM
Last ModifiedFeb 10 2012 10:37AM
CommentThe ThiI protein of Escherichia coli is a bifunctional protein in which most of the length of the protein is responsible for sulfurtransferase activity in 4-thiouridine modification to tRNA (EC 2.8.1.4 - see model TIGR00342). This rhodanese-like C-terminal domain, by itself, is able to synthesize the thiazole moiety during thiamin biosynthesis. Note that the invariant Cys residue in this domain is unusual in being required for both activities of the bifunctional ThiI protein.
ReferencesRN [1] RM PMID:21724998 RT The rhodanese domain of ThiI is both necessary and sufficient for synthesis of the thiazole moiety of thiamine in Salmonella enterica. RA Martinez-Gomez NC, Palmer LD, Vivas E, Roach PL, Downs DM RL J Bacteriol. 2011 Sep;193(18):4582-7. Epub 2011 Jul 1.
Genome PropertyGenProp0250: thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly (HMM)
GenProp0250: thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly (HMM)
GenProp0250: thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly (HMM)