HMM Summary Page: TIGR04274
| Accession | TIGR04274 |
| Name | hypoxanDNAglyco |
| Function | DNA-deoxyinosine glycosylase |
| Trusted Cutoff | 80.00 |
| Domain Trusted Cutoff | 80.00 |
| Noise Cutoff | 50.00 |
| Domain Noise Cutoff | 50.00 |
| Isology Type | equivalog |
| EC Number | 3.2.2.15 |
| HMM Length | 150 |
| Author | Haft DH |
| Entry Date | Feb 1 2012 2:12PM |
| Last Modified | Feb 1 2012 3:01PM |
| Comment | Members of this protein family represent family 6 of the uracil-DNA glycosylase superfamily, where the five previously described families all act as uracil-DNA glycosylase (EC 3.2.2.27) per se. This family, instead, acts as a hypoxanthine-DNA glycosylase, where hypoxanthine results from deamination of adenine. Activity was shown directly for members from Methanosarcina barkeri and Methanosarcina acetivorans. |
| References | RN [1] RM PMID:21642431 RT New family of deamination repair enzymes in uracil-DNA glycosylase superfamily. RA Lee HW, Dominy BN, Cao W RL J Biol Chem. 2011 Sep 9;286(36):31282-7. |