HMM Summary Page: TIGR04344

Function5-histidylcysteine sulfoxide synthase
Gene SymbolovoA
Trusted Cutoff400.00
Domain Trusted Cutoff400.00
Noise Cutoff325.00
Domain Noise Cutoff325.00
Isology Typeequivalog_domain
HMM Length444
AuthorHaft DH
Entry DateJun 22 2012 3:01PM
Last ModifiedAug 12 2012 6:56PM
CommentOvothiol A is N1-methyl-4-mercaptohistidine. In the absence of S-adenosylmethione, a methyl donor, the intermediate produced is 4-mercaptohistidine. In both Erwinia tasmaniensis and Trypanosoma cruzi, a protein occurs with 5-histidylcysteine sulfoxide synthase activity, but these two enzymes and most homologs share an additional C-terminal methyltransferase domain. Thus OvoA may be a bifunctional enzyme with 5-histidylcysteine sulfoxide synthase and 4-mercaptohistidine N1-methyltranferase activity. This model describes the 5-histidylcysteine sulfoxide synthase domain, a homolog of the ergothioneine biosynthesis protein EgtB.
ReferencesRN [1] RM PMID:21247153 RT Identification and characterization of the first ovothiol biosynthetic enzyme. RA Braunshausen A, Seebeck FP RL J Am Chem Soc. 2011 Feb 16;133(6):1757-9. RN [2] RM PMID:9022682 RT Studies on the biosynthesis of ovothiol A. Identification of 4-mercaptohistidine as an intermediate. RA Steenkamp DJ, Weldrick D, Spies HS RL Eur J Biochem. 1996 Dec 15;242(3):557-66.
Genome PropertyGenProp1064: ovothiol biosynthesis (HMM)