HMM Summary Page: TIGR04345

AccessionTIGR04345
NameovoA_Cterm
Functionputative 4-mercaptohistidine N1-methyltranferase
Trusted Cutoff170.00
Domain Trusted Cutoff170.00
Noise Cutoff155.00
Domain Noise Cutoff155.00
Isology Typeequivalog_domain
HMM Length242
AuthorHaft DH
Entry DateJun 22 2012 3:16PM
Last ModifiedAug 12 2012 6:56PM
CommentOvothiol A is N1-methyl-4-mercaptohistidine. In the absence of S-adenosylmethione, a methyl donor, the intermediate produced is 4-mercaptohistidine. In both Erwinia tasmaniensis and Trypanosoma cruzi, a protein occurs with 5-histidylcysteine sulfoxide synthase activity, but these two enzymes and most homologs share an additional C-terminal methyltransferase domain. Thus OvoA may be a bifunctional enzyme with 5-histidylcysteine sulfoxide synthase and 4-mercaptohistidine N1-methyltranferase activity. This model describes C-terminal putative 4-mercaptohistidine N1-methyltranferase domain.
ReferencesRN [1] RM PMID:21247153 RT Identification and characterization of the first ovothiol biosynthetic enzyme. RA Braunshausen A, Seebeck FP RL J Am Chem Soc. 2011 Feb 16;133(6):1757-9.
Genome PropertyGenProp1064: ovothiol biosynthesis (HMM)